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CME: Acute Lymphoblastic Leukemia (ALL): Highlights from the 2015 American Society of Clinical Oncology (ASCO)

Activity Description / Statement of Need:

In this online CME self-learning program:

 

Acute lymphoblastic leukemia (ALL) is one of a group of malignancies caused by cytogenetic DNA mutations of developing hematopoietic stem cell precursors and mostly common to children with peak incidence at 2-5 years of age. Although approximately 80% of ALL cases present in children, they also occur in adults.  The symptoms of ALL are non-specific and similar to those of acute myelogenous leukemia (ALL), which patients usually have 1-3 months of complaints.  These symptoms include: fatigue, malaise, or palpitations associated with anemia; fever with or without infection due to leukopenia or leukocytosis; and petechiae, and bleeding or bruising of the oral mucosa, skin, or gastrointestinal tract due to thrombocytopenia. Treatment goal in patients with ALL is to cure (which is defined as remission for at least 5 years), with children commonly responding to treatment with better than adults. Children may have a remission rate of 99% with a cure rate of about 90%, whereas adults have remission rates of only 60-85% with only 30-40% reaching 5-year disease-free survival. Treatments are categorized into five phases: remission induction with CNS prophylaxis, consolidation therapy, interim maintenance, delayed intensification, and maintenance therapy.  Despite the high rate of cure in patients, possible complications and barriers to care in the treatment of ALL are adverse effects, expensive cost of treatment, or poor diagnosis. Dozens of agents that directly target biochemical pathways essential to neoplastic processes have been recently discovered and have been studied specifically in ALL, some of which are FDA-approved for ALL, others of which are presently in clinical trials. Helping the clinician discern the role of both cytotoxic and more novel therapies merits continuing education programming in ALL.

 

Agenda

 

Discussion and summary of impactful research abstracts and symposia presented at ASCO 2015 on the topic of ALL


Target Audience:

 

Healthcare professionals specializing in: hematology, oncology, and those who otherwise commonly care for patients with ALL.


Commercial Support Disclosure: This program is supported by educational grants from Sigma-Tau.


Release Date: July 31, 2015 -- Expiration Date: July 30, 2017

Faculty: Gary Schiller, MD

Agenda

Learning Objectives

By the end of the session the participant will be able to:

  • 1. In the area of initial management of ALL, summarize the most impactful findings presented at ASCO 2015 relating to ALL and apply them to patient cases, taking into account any relevant barriers to care.
  • 2. In the area of resistant disease, summarize the most impactful findings presented at ASCO 2015 relating to ALL and apply them to patient cases, taking into account any relevant barriers to care.

Accreditation

ACCREDITATION FOR THIS COURSE HAS EXPIRED. YOU MAY VIEW THE PROGRAM, BUT CME / CE IS NO LONGER AVAILABLE AND NO CERTIFICATE WILL BE ISSUED.

Faculty Disclosure and Resolution of COI

 As a provider of continuing medical education, it is the policy of ScientiaCME to ensure balance, independence, objectivity, and scientific rigor in all of its educational activities. In accordance with this policy, faculty and educational planners must disclose any significant relationships with commercial interests whose products or devices may be mentioned in faculty presentations, and any relationships with the commercial supporter of the activity. The intent of this disclosure is to provide the intended audience with information on which they can make their own judgments. Additionally, in the event a conflict of interest (COI) does exist, it is the policy of ScientiaCME to ensure that the COI is resolved in order to ensure the integrity of the CME activity. For this CME activity, any COI has been resolved thru content review ScientiaCME.

 

Faculty Disclosure: Gary J. Schiller, MD, discloses having financial arrangements or affiliations with the following commercial interest(s) whose products or services may be mentioned in this activity: Spectrum, Amgen, Onyx, and Pfizer.

 

 

Disclosures of Educational Planners: Charles Turck, PharmD is an officer and part owner of ScientiaCME, LLC.

 

Commercial Support Disclosure: This program is supported by educational grants from Sigma-Tau.

Instructions

  • Read the learning objectives above
  • Take the Pre-Test (optional). Completion of the pre-test will help us evaluate the knowedge gained by participating in this CME activity.
  • View the online activity. You may view this is in more than one session, and may pause or repeat any portion of the presentation if you need to.
  • Take the post-test
  • Complete the activity evaluation and CME registration. A CE certificate will be emailed to you immediately.

Cultural and Linguistic Competence

System Requirements

PC
Windows 7 or above
Internet Explorer 8
*Adobe Acrobat Reader
MAC
Mac OS 10.2.8
Safari or Chrome or Firefox
*Adobe Acrobat Reader
Internet Explorer is not supported on the Macintosh

*Required to view Printable PDF Version


Perform Pre-Test (optional)

Please take a few minutes to participate in the optional pre-test. It will help us measure the knowledge gained by participating in this activity.


Additional Courses That Are Related To This Activity

Acute Lymphoblastic Leukemia (ALL): Highlights from the 2015 American Society of Hematology: Take-Aways, Emerging Practice Changes, and Barriers to their Implementation

Acute Lymphoblastic Leukemia (ALL): Highlights from the 2016 American Society for Clinical Oncology: Take-Aways, Emerging Practice Changes, and Barriers to their Implementation

Acute Lymphoblastic Leukemia (ALL): Highlights from the 2016 American Society of Hematology (ASH 2016): Take-Aways, Emerging Practice Changes, and Barriers to their Implementation

Adult Acute Lymphoblastic Leukemia (ALL) in Adults: 2015 Overview