Forgot Password?
Return to Course Listing

CME: The Newest in Non-Small Cell Lung Cancer (NSCLC): Emerging Therapies, Novel Approaches, Therapeutic Updates, and Barriers to Care and Incorporating Best Practice

Activity Description / Statement of Need:

In this online CME self-learning program:

Lung cancer is the leading cause of cancer-related death in the United States with nearly 221,000 new cases diagnosed and 156,390 deaths annually. While surgery in eligible candidates and early detection provide the best chances for cure, there are many patients who must be treated by alternative modalities, including those with advanced disease.  Increasingly now, research is uncovering the role of biomarkers and genetic mutations in aiding not only the prognosis of NSCLC, but also its management.  They have given rise to targeted therapies that mechanistically alter cellular signaling pathways in a manner that suppresses angiogenesis and oncologic disease progression.


On the practical side, the literature also suggests that: there are or may be emerging or existing patterns of disparities in healthcare, treatment, and outcomes of patients with NSCLC on the basis of race, disability, and insurance coverage.  In particular, race- and ethnicity-based discrimination within the healthcare environment are associated with disparities in care; and that such discrimination is associated with both worse chronic health condition control and a higher incidence catastrophic health events.


This program has been designed to bring healthcare professionals’ knowledge of the rationale behind treatment of NSCLC up to date and to enhance their competence in caring for patients with NSCLC.  This program also attempts to examine the role of disparities in care of patients with NSCLC and strategies to minimize or alleviate those disparities.




Faculty introduction, disclosures

Introductory content, pathophysiology, and histopathology  

  • Epidemiology: statistics by severity
  • Lesion biopsy timing, adequacy of tissue sample volume, histopathology and subtypes
  • Pathogenesis and the role of the immune system
  • Updates in biomarkers, staging, and mutation statues

Updates in treatment in patients with NSCLC 

  • Clinical trials: what is new, and how should it impact practice?
  • Appropriate and approved molecular testing, biomarker analysis, and genetic mutations, and use thereof to guide treatment
  • Therapy sequencing
  • Clinical pearls: safety, tolerability, educating the patient (including managing treatment expectations), improving the provider-patient relationship, and those factors’ impact patient outcomes, including adherence to therapy
  • Emerging therapeutic options for NSCLC: what is on the horizon?
  • Patient case(s)

Summary, conclusions, and best practice recap

Target Audience:


Healthcare professionals specializing in: interventional radiology; nuclear medicine; oncology; palliative care; pathology; pulmonology; or those who otherwise commonly care for patients with NSCLC.

Commercial Support Disclosure: This program is supported by an educational grant from Boehringer Ingelheim

Release Date: May 09, 2016 -- Expiration Date: May 09, 2018

Faculty: Deepa Subramaniam, MD MSc


Learning Objectives

By the end of the session the participant will be able to:

  • Describe the impact of biomarker and mutation testing and their results for the management of patients with NSCLC and apply this knowledge to patient cases.
  • Describe the role and impact of the initial biopsy, including the relevance of its timing and factors affecting quality of results.
  • Distinguish between different NSCLC disease subtypes on the basis of histology, biomarker, and mutation status and use the information to optimize care in the setting of patient cases.
  • Discuss the ways that NSCLC has proved resistant to treatments in past and the mechanisms of action of targeted therapies, present and emerging
  • Determine how to incorporate the following components into a NSCLC treatment regimen in a manner that optimizes efficacy, safety, and tolerability: sequencing, dose reduction, and biomarker and mutation status testing



Faculty Disclosure and Resolution of COI

 As a provider of continuing medical education, it is the policy of ScientiaCME to ensure balance, independence, objectivity, and scientific rigor in all of its educational activities. In accordance with this policy, faculty and educational planners must disclose any significant relationships with commercial interests whose products or devices may be mentioned in faculty presentations, and any relationships with the commercial supporter of the activity. The intent of this disclosure is to provide the intended audience with information on which they can make their own judgments. Additionally, in the event a conflict of interest (COI) does exist, it is the policy of ScientiaCME to ensure that the COI is resolved in order to ensure the integrity of the CME activity. For this CME activity, any COI has been resolved thru content review ScientiaCME.


Faculty Disclosure: Deepa Subramaniam, MD has received financial compensation from AstraZeneca (consultant)


Disclosures of Educational Planners: Charles Turck, PharmD is an officer and part owner of ScientiaCME, LLC.


Commercial Support Disclosure: This program is supported by an educational grant from Boehringer Ingelheim


  • Read the learning objectives above
  • Take the Pre-Test (optional). Completion of the pre-test will help us evaluate the knowedge gained by participating in this CME activity.
  • View the online activity. You may view this is in more than one session, and may pause or repeat any portion of the presentation if you need to.
  • Minimum participation threshold: Take the post-test. A score of 0% or higher is required to pass and proceed to the activity evaluation.
  • Complete the activity evaluation and CME registration. A CE certificate will be emailed to you immediately.

Cultural and Linguistic Competence

System Requirements

Windows 7 or above
Internet Explorer 8
*Adobe Acrobat Reader
Mac OS 10.2.8
Safari or Chrome or Firefox
*Adobe Acrobat Reader
Internet Explorer is not supported on the Macintosh

*Required to view Printable PDF Version

Perform Pre-Test (optional)

Please take a few minutes to participate in the optional pre-test. It will help us measure the knowledge gained by participating in this activity.

Additional Courses That Are Related To This Activity

Advances in Treating Metastatic Colorectal Cancer (CRC): Optimizing Recognition and Pharmacotherapeutic Management Strategies

Non-Small Cell Lung Cancer (NSCLC): Highlights from the 2016 American Society for Clinical Oncology: Take-Aways, Emerging Practice Changes, and Barriers to their Implementation

Metastatic Melanoma: Novel Approaches in Immuno- and Molecularly- Targeted Therapy, Therapeutic Updates, and Best Practices in Involving the Patient in Care

Advancing Treatment Strategies in Multiple Myeloma (MM) Drug Therapy