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CME: Chronic Idiopathic Constipation (CIC): Optimizing Pharmacotherapeutic Management Strategies


Activity Description / Statement of Need:


Chronic idiopathic constipation (CIC) is a clinical condition comprised of a myriad of etiologies and subgroup that affects between fourteen and 28 percent of the U.S. population. Not only is it prevalent, but it is also expensive; it results in anywhere between two and a half and seven million healthcare visits each year at a cost of $29 billion. In spite of its widespread impact, it is thought to be underreported due to social perceptions and lack of a clear-cut definition for constipation. Symptoms may arise: as a result of poor nutrition, sedentary lifestyle, demographic predisposition; secondary to an adverse drug effect; from neuropsychiatric conditions; or completely idiopathically.




  • Daily intestinal fluid balance
  • Salivary and succus enterricus composition
  • Anatomical and physiological review
  • Rome IV Criteria
  • Primary and secondary causes of constipation
  • Physical exam
  • Colorectal structure and motility
  • Diagnosis of chronic constipation
  • Treatments: bulk forming laxatives, osmotic laxatives, stimulant laxatives, emollients & surfactants, chloride channel activator, uroguanylin analog
  • Food diversity
  • The microbiome

Target Audience:

The following healthcare professionals: gastroenterologists and primary care physicians; physician assistants, nurse practitioners, nurses, and pharmacists who practice in gastroenterology; and any other healthcare professionals with an interest in or who clinically encounter patients with chronic idiopathic constipation.

This program is supported by an educational grant from Synergy Pharmaceuticals

Release Date: October 02, 2017 -- Expiration Date: October 02, 2019

Faculty: Joseph Weiss, MD


Learning Objectives

By the end of the session the participant will be able to:

  • Describe the pathophysiology of chronic idiopathic constipation
  • Describe the benefits and risks of pharmacotherapy for chronic idiopathic constipation and take them into account when formulating a treatment plan for different patients
  • Formulate an evidence-based treatment plan for a variety of patients with chronic idiopathic constipation.
  • Recommend therapy changes in patients with chronic idiopathic constipation who do not respond to a previously prescribed treatment



Faculty Disclosure and Resolution of COI

 As a provider of continuing medical education, it is the policy of ScientiaCME to ensure balance, independence, objectivity, and scientific rigor in all of its educational activities. In accordance with this policy, faculty and educational planners must disclose any significant relationships with commercial interests whose products or devices may be mentioned in faculty presentations, and any relationships with the commercial supporter of the activity. The intent of this disclosure is to provide the intended audience with information on which they can make their own judgments. Additionally, in the event a conflict of interest (COI) does exist, it is the policy of ScientiaCME to ensure that the COI is resolved in order to ensure the integrity of the CME activity. For this CME activity, any COI has been resolved thru content review ScientiaCME.


Faculty Disclosure:   Joseph Weiss, MD, FACP, FACG, AGAF,  Clinical Professor of Medicine University of California, San Diego has no relevant conflicts of interest to disclose.


Disclosures of Educational Planners: Charles Turck, PharmD, BCPS, BCCCP has no relevant conflicts of interest to disclose.


Commercial Support Disclosure: This program is supported by an educational grant from Synergy Pharmaceuticals


  • Read the learning objectives above
  • Take the Pre-Test (optional). Completion of the pre-test will help us evaluate the knowledge gained by participating in this CME activity.
  • View the online activity. You may view this is in more than one session, and may pause or repeat any portion of the presentation if you need to.
  • Minimum participation threshold: Take the post-test. A score of 70% or higher is required to pass and proceed to the activity evaluation.
  • Complete the activity evaluation and CME registration. A CE certificate will be emailed to you immediately.

Cultural/Linguistic Competence & Health Disparities

System Requirements

Windows 7 or above
Internet Explorer 8
*Adobe Acrobat Reader
Mac OS 10.2.8
Safari or Chrome or Firefox
*Adobe Acrobat Reader
Internet Explorer is not supported on the Macintosh

*Required to view Printable PDF Version

Perform Pre-Test (optional)

Please take a few minutes to participate in the optional pre-test. It will help us measure the knowledge gained by participating in this activity.

Additional Courses That Are Related To This Activity

Therapeutic updates and best practices in the treatment of irritable bowel syndrome with constipation (IBS-C)