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CME: Updates in Hereditary Angioedema (HAE) Pharmacotherapy: The Present State of Care

Activity Description / Statement of Need:

In this online CME self-learning program:

 

Hereditary angioedema (HAE) is a rare, debilitating, and potentially life-threatening disease due to C1-inhibitor (C1-INH) deficiency with an estimated frequency of 1 in 50,000 people.HAE is characterized by recurrent edema attacks and the cutaneous attacks can be disabling, with the skin, gastrointestinal tract, and upper airways are most commonly affected and with a persistent risk to the patient of acute events of laryngeal swelling that may prove fatal if not treated in a timely manner.Angioedema in general can be confused with cellulitis, Graves disease, blepharochalasis, eosinophilic fasciitis, or amyloidosis which can lead to delays in diagnosis, and inappropriate treatment poses the risk of adverse events, unnecessary surgical interventions, a higher burden of misery, and a potentially higher rate of morbidity and mortality.

Target Audience:

Healthcare professionals who are: allergists or immunologists; physician assistants; nurse practitioners; pharmacists; or those otherwise treat or clinically encounter patients with HAE.


This activity is supported by an educational grant from CSL Behring.


Release Date: April 20, 2018 -- Expiration Date: April 20, 2020

Faculty: Michael Frank, MD

Agenda



Epidemiology, pathophysiology, and diagnosis of HAE

  • Definition and role in history
  • Causes
  • Biochemistry: mast cell degranulation, activation, and mediator release; roles of bradykinin, C1-INH
  • Distinction from acquired and ACEi angioedema
  • Incidence
  • Clinical features
  • Diagnosis
  • Patient case(s)

Pharmacotherapeutic management of HAE

  • Prevention is the best medicine: triggers and their avoidance
  • Emergency evaluation, airway compromise: Ishoo staging system
  • Pharmacotherapy detailing: review and updates, acute and prophylactic therapy
  • Best practice: putting it all together
  • Barriers to care
  • Patient case(s)

Learning Objectives

By the end of the session the participant will be able to:

  • Describe the clinical presentation of HAE, its differential diagnosis, and how it is determined to be different from other forms of angioedema
  • Explain the importance of early diagnosis of HAE and screening in patients who are at high risk
  • Evaluate a treatment plan for a patient with HAE designed to optimize safety and efficacy, suggesting modifications for improvement
  • Identify challenges and barriers to optimal care in HAE

Accreditation

ACCREDITATION FOR THIS COURSE HAS EXPIRED. YOU MAY VIEW THE PROGRAM, BUT CME / CE IS NO LONGER AVAILABLE AND NO CERTIFICATE WILL BE ISSUED.

Faculty Disclosure and Resolution of COI

As a provider of continuing medical education, it is the policy of ScientiaCME to ensure balance, independence, objectivity, and scientific rigor in all of its educational activities. In accordance with this policy, faculty and educational planners must disclose any significant relationships with commercial interests whose products or devices may be mentioned in faculty presentations, and any relationships with the commercial supporter of the activity. The intent of this disclosure is to provide the intended audience with information on which they can make their own judgments. Additionally, in the event a conflict of interest (COI) does exist, it is the policy of ScientiaCME to ensure that the COI is resolved in order to ensure the integrity of the CME activity. For this CME activity, any COI has been resolved thru content review ScientiaCME.

 

Faculty Disclosures:


Dr. Michael Frank, MD, the Samuel L. Katz Professor of Pediatrics. Professor of Medicine and Immunology Duke University, Durham, NC has received consulting income from Shire and  Biocryst

 

Disclosures of Educational Planners: Charles Turck, PharmD, BCPS, BCCCP has no relevant conflicts of interest to disclose.

 

Commercial Support Disclosure: This program is supported by an educational grant from CSL Behring.

Samuel
L.
Katz
Professor
of
Pediatrics.
Professor
of
Medicine
and
Immunology
Duke
University

Instructions

  • Read the learning objectives above
  • Take the Pre-Test (optional). Completion of the pre-test will help us evaluate the knowedge gained by participating in this CME activity.
  • View the online activity. You may view this is in more than one session, and may pause or repeat any portion of the presentation if you need to.
  • Take the post-test
  • Complete the activity evaluation and CME registration. A CE certificate will be emailed to you immediately.

Cultural and Linguistic Competence

System Requirements

PC
Windows 7 or above
Internet Explorer 8
*Adobe Acrobat Reader
MAC
Mac OS 10.2.8
Safari or Chrome or Firefox
*Adobe Acrobat Reader
Internet Explorer is not supported on the Macintosh

*Required to view Printable PDF Version


Perform Pre-Test (optional)

Please take a few minutes to participate in the optional pre-test. It will help us measure the knowledge gained by participating in this activity.


Additional Courses That Are Related To This Activity

Hereditary Angioedema (HAE): Therapeutic Updates, Best Practices, and Barriers to Care

Primary Immunodeficiency: Updates to Screening & Treatment