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CME: Hypoparathyroidism: therapeutic updates and optimizing treatment


Activity Description / Statement of Need:

In this online, self-learning activity:


Hypoparathyroidism is a rare disorder characterized by decreased function of parathyroid glands resulting in low levels of parathyroid hormone (PTH). There may be a variety of causes that include autoimmune disease, congenital defects, unintended removal during thyroidectomy, or as a result of damage due to radiation therapy. In a normal functioning parathyroid gland, PTH is secreted in response to low serum-ionized calcium. Patients with hypoparathyroidism experience abnormal mineral homeostasis affecting bone, kidney, and the gastrointestinal tract. Pathogenesis of the condition includes reduced osteoclast-mediated bone resorption, reduced calcium reabsorption in the distal convoluted tubules of the kidneys, and increased phosphorus reabsorption from the proximal convoluted tubules, causing hyperphosphatemia. In severe, untreated cases, hypocalcemia can result in abnormal skeletal formation, cognitive impairment, bronchospasms, laryngospasms, neuromuscular irritability and cardiac issues.

Target Audience:

The following healthcare professionals: endocrinologists and primary care physicians; physician assistants, nurse practitioners, nurses, and pharmacists who practice in endocrinology and internal medicine; and any other healthcare professionals with an interest in or who clinically encounter patients with hypoparathyroidism.

Commercial Support Disclosure: This program is supported by an educational grant from Shire.

Release Date: June 06, 2018 -- Expiration Date: June 06, 2020

Faculty: Angela Leung, MD, MSc


Introduction, Disclosures

The epidemiology and clinical features of hypoparathyroidism

  • Understanding the prevalence and recognizing the most common causes of hypoparathyroidism in the US.
  • Clinical presentation and diagnosis
  • The pathophysiologic relationship between hypoparathyroidism and its complications

Treatment of hypoparathyroidism

  • Goals of therapy
  • Management of mineral homeostasis caused by the disorder
  • Therapeutic interventions available
  • Emerging therapies
  • Adverse effects of available treatment options
  • Patient case(s)

Barriers to optimal care

  • Limited knowledge of the disorder
  • Limited treatment options available
  • Effects on QOL

Summary and conclusions

Learning Objectives

By the end of the session the participant will be able to:

  • Describe the pathophysiology and underlying etiologies of hypoparathyroidism and apply these to patient cases.
  • Describe the clinical manifestations of hypoparathyroidism and discuss how they may have relevance to treatment targets.
  • Identify available therapeutic options for hypoparathyroidism and incorporate these in the development of treatment plans in patient cases.
  • Define patient-specific goals related to the management of hypoparathyroidism.


ACCME Activity #201226425


Faculty Disclosure and Resolution of COI

As a provider of continuing medical education, it is the policy of ScientiaCME to ensure balance, independence, objectivity, and scientific rigor in all of its educational activities. In accordance with this policy, faculty and educational planners must disclose any significant relationships with commercial interests whose products or devices may be mentioned in faculty presentations, and any relationships with the commercial supporter of the activity. The intent of this disclosure is to provide the intended audience with information on which they can make their own judgments. Additionally, in the event a conflict of interest (COI) does exist, it is the policy of ScientiaCME to ensure that the COI is resolved in order to ensure the integrity of the CME activity. For this CME activity, any COI has been resolved thru content review ScientiaCME.


Faculty Disclosure: Dr.  Angela M. Leung, M.D., M.S.c., UCLA David Geffen School of Medicine, Los Angeles, CA is a consultant , speakers bureau member, or on the editorial board of: American Thyroid Association, Medical Education Resources, Mundipharma Inc, and Versar Inc


Disclosures of Educational Planners: Charles Turck, PharmD, BCPS, BCCCP has no relevent financial disclosures.


Commercial Support Disclosure: This program is supported by an educational grant from Shire.


  • Read the learning objectives above
  • Take the Pre-Test (optional). Completion of the pre-test will help us evaluate the knowledge gained by participating in this CME activity.
  • View the online activity. You may view this is in more than one session, and may pause or repeat any portion of the presentation if you need to.
  • Minimum participation threshold: Take the post-test. A score of 70% or higher is required to pass and proceed to the activity evaluation.
  • Complete the activity evaluation and CME registration. A CE certificate will be emailed to you immediately.

Cultural/Linguistic Competence & Health Disparities

System Requirements

Windows 7 or above
Internet Explorer 8
*Adobe Acrobat Reader
Mac OS 10.2.8
Safari or Chrome or Firefox
*Adobe Acrobat Reader
Internet Explorer is not supported on the Macintosh

*Required to view Printable PDF Version

Perform Pre-Test (optional)

Please take a few minutes to participate in the optional pre-test. It will help us measure the knowledge gained by participating in this activity.