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CME: Frontiers in the Pharmacotherapeutic Management of Osteoporosis


Activity Description / Statement of Need:

In this online, self-learning activity:

Osteoporosis is a disease common among elderly patients that is increasing in frequency as senior citizens begin to represent a larger share of the U.S. population. Osteoporosis increases the risk of severe fracture, which, in turn, is associated with a higher risk of mortality. A variety of literature has demonstrated that antiresorptive therapy is effective at reducing the progression of disease and preventing fracture; however, recent studies have demonstrated that these therapies have a variety of adverse effects,some of which – like osteonecrosis of the jaw and atypical fractures – are severe and were unrecognized at the time of their initial FDA approval. These emerging concerns are raising questions as to the optimal duration of treatment and potential benefit of a drug holiday.

Target Audience:

The following healthcare professionals: endocrinologists, geriatricians, internists; physician assistants, nurse practitioners, nurses, and pharmacists who specialize in those areas of medicine; those who otherwise commonly care for patients with osteoporosis.

Commercial Support Disclosure: This program is supported by an educational grant from Radius Health.

Release Date: September 30, 2018 -- Expiration Date: September 30, 2020

Faculty: Yousaf Ali, MD, FACR


Faculty introduction, disclosures

Introduction content: cursory refresher and review of osteoporosis

  • Epidemiology
  • Definitions and types of osteoporosis
  • Causes and risk factors
  • Bone mineral density, dual-energy X-ray absorptiometry, T-scores, and bone metabolic biomarkers
  • Differential diagnosis: ruling out vitamin D deficiency and other endocrine and metabolic disorders
  • Patient cases

Treatment and prevention of osteoporosis

  • Clinical trial findings and guideline updates
  • A review of present pharmacotherapy; present controversies and risks to include:
  • atrial fibrillation
  • esophageal cancer
  • atypical fractures
  • osteonecrosis of the jaw
  • acute renal failure
  • REMS guidelines
  • dermatologic reactions
  • infections
  • osteosarcoma
  • patient education burden
  • Other clinical pearls
  • Emerging and future therapies, including: mechanisms of action, potential places in therapy, and patient-specific treatment considerations
  • The roles of exercise, diet, calcium, and vitamins in osteoporosis
  • Other lifestyle factors: smoking cessation, limitation of alcohol and caffeine consumption as considerations in osteoporosis
  • Optimizing patients’ adherence to their therapy
  • Patient case(s)

Summary, conclusions, and best practice recap

Learning Objectives

By the end of the session the participant will be able to:

  • List the causes and risk factors for development of osteoporosis or osteopenia
  • Describe the relative efficacy, safety, and place in therapy of presently available agents used to treat and prevent osteoporosis
  • Identify investigational pharmacotherapeutic treatments for management of osteoporosis, and describe their mechanisms of action and likely place in therapy
  • Using pertinent patient-specific information, recommend an appropriate pharmacotherapeutic treatment plan for the management of a given patient�s osteoporosis or osteopenia



Faculty Disclosure and Resolution of COI

As a provider of continuing medical education, it is the policy of ScientiaCME to ensure balance, independence, objectivity, and scientific rigor in all of its educational activities. In accordance with this policy, faculty and educational planners must disclose any significant relationships with commercial interests whose products or devices may be mentioned in faculty presentations, and any relationships with the commercial supporter of the activity. The intent of this disclosure is to provide the intended audience with information on which they can make their own judgments. Additionally, in the event a conflict of interest (COI) does exist, it is the policy of ScientiaCME to ensure that the COI is resolved in order to ensure the integrity of the CME activity. For this CME activity, any COI has been resolved thru content review ScientiaCME.


Faculty Disclosure: Dr. Ali, MD, Associate Professor of Medicine, Icahn School of Medicine at Mount Sinai, has no relevant financial disclosures.


Disclosures of Educational Planners: Charles Turck, PharmD has no relevent financial disclosures.


Commercial Support Disclosure: This activity is supported by an educational grant from Radius Health.


  • Read the learning objectives above
  • Take the Pre-Test (optional). Completion of the pre-test will help us evaluate the knowledge gained by participating in this CME activity.
  • View the online activity. You may view this is in more than one session, and may pause or repeat any portion of the presentation if you need to.
  • Minimum participation threshold: Take the post-test. A score of 70% or higher is required to pass and proceed to the activity evaluation.
  • Complete the activity evaluation and CME registration. A CE certificate will be emailed to you immediately.

Cultural/Linguistic Competence & Health Disparities

System Requirements

Windows 7 or above
Internet Explorer 8
*Adobe Acrobat Reader
Mac OS 10.2.8
Safari or Chrome or Firefox
*Adobe Acrobat Reader
Internet Explorer is not supported on the Macintosh

*Required to view Printable PDF Version

Perform Pre-Test (optional)

Please take a few minutes to participate in the optional pre-test. It will help us measure the knowledge gained by participating in this activity.

Additional Courses That Are Related To This Activity

Optimizing Primary and Secondary Fracture Prevention in Men with Osteoporosis

Male Osteoporosis Management: Advances in Pharmacotherapy

Osteoporosis Management: Advances in Pharmacotherapy