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CME: Advanced Prostate Cancer (aPC): Therapeutic Updates, Best Practices, and Emerging Treatments


Activity Description / Statement of Need:

In this online, self-learning activity:

Prostate cancer is the most common form of malignancy among men in the United States.There are over 164,600 new cases and over 29,000 deaths from PC in the U.S. annually. Probable risk factors include age 65 and older, African American ancestry, family history, and mutations in the BRCA1, -2, MSH2, and HOXB13 genes, with possible risk factors including occupational exposure to cadmium, dietary factors, and higher concentrations of serum testosterone. About 95% of cases are adenocarcinoma, with neuroendocrine tumors, sarcomas, and transitional cell carcinomas comprising the balance of tumor types. Symptoms of advanced prostate cancer (aPC) include back pain, cord compression, lower extremity edema, pathologic fractures, anemia, and weight loss.

Target Audience:

The following HCPs: oncologists and urologists; physician assistants, nurse practitioners, nurses, and pharmacists specializing in oncology; and any other HCPs with an interest in or who may clinically encounter patients with aPC.

Commercial Support Disclosure: This program is supported by educational grants from Sanofi / Genzyme.

This activity is free of charge.

Release Date: May 05, 2019 -- Expiration Date: May 05, 2021

Faculty: David Wise, MD


  • Epidemiology and etiology of aPC: statistics
  • Risk factors
  • Pathophysiology
  • Symptomology and diagnosis of aPC 
  • Classification
  • Prognosis and progression of disease
  • Complications: cardiovascular, importance and risk of bone health

        Treatment in patients with aPC

  • Nonpharmacologic
  • Contemporary pharmacotherapeutic treatment landscape
  • Hormone-sensitive, castration-resistant
  • Immunotherapy
  • Outcomes
  • Investigational agents

Learning Objectives

By the end of the session the participant will be able to:

  • Describe the pathophysiology of aPC
  • Identify the present treatment options currently available for management of aPC
  • Evaluate the safety and effectiveness of certain treatment options in specific patient populations and apply this knowledge to patient cases using evidence-based medicine
  • Describe complications associated with prostate cancer and its treatment (bone, cardiovascular, and endocrinologic risk factors) and develop risk mitigation and optimization strategies



Faculty Disclosure and Resolution of COI

As a provider of continuing medical education, it is the policy of ScientiaCME to ensure balance, independence, objectivity, and scientific rigor in all of its educational activities. In accordance with this policy, faculty and educational planners must disclose any significant relationships with commercial interests whose products or devices may be mentioned in faculty presentations, and any relationships with the commercial supporter of the activity. The intent of this disclosure is to provide the intended audience with information on which they can make their own judgments. Additionally, in the event a conflict of interest (COI) does exist, it is the policy of ScientiaCME to ensure that the COI is resolved in order to ensure the integrity of the CME activity. For this CME activity, any COI has been resolved thru content review ScientiaCME.

Faculty Disclosure:

David Wise, M.D., Attending Medical Oncologist, Genitourinary Cancers Program, Perlmutter Cancer Center at NYU, discloses that he has received research or speakers bureau funding from Foundation Medicine, LEAP Therapeutics, Best Doctors, Guidepoint, and GLG.

Disclosures of Educational Planners: Charles Turck, PharmD has no relevant financial discloses.

Commercial Support Disclosure: This program is supported by educational grants from Sanofi / Genzyme


  • Read the learning objectives above
  • Take the Pre-Test (optional). Completion of the pre-test will help us evaluate the knowledge gained by participating in this CME activity.
  • View the online activity. You may view this is in more than one session, and may pause or repeat any portion of the presentation if you need to.
  • Minimum participation threshold: Take the post-test. A score of 70% or higher is required to pass and proceed to the activity evaluation.
  • Complete the activity evaluation and CME registration. A CE certificate will be emailed to you immediately.

Cultural/Linguistic Competence & Health Disparities

System Requirements

Windows 7 or above
Internet Explorer 8
*Adobe Acrobat Reader
Mac OS 10.2.8
Safari or Chrome or Firefox
*Adobe Acrobat Reader
Internet Explorer is not supported on the Macintosh

*Required to view Printable PDF Version

Perform Pre-Test (optional)

Please take a few minutes to participate in the optional pre-test. It will help us measure the knowledge gained by participating in this activity.

Additional Courses That Are Related To This Activity

Addressing skeletal-related events in prostate cancer

Advanced prostate cancer: Optimizing management strategies

Ovarian Cancer: Therapeutic Updates, Best Practices, and Emerging Treatments

Treating Oncology Patients During COVID-19