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CME: Human Immunodeficiency Virus (HIV): Optimizing pharmacotherapeutic management strategies


Activity Description / Statement of Need:

In this online CME self-learning activity:

According to the CDC, there are more than 1.1 million people aged thirteen and older living with HIV (PLWH). Since the beginning of the HIV epidemic in the 1980s, advances in public health initiatives and treatments have considerably lengthened the life expectancy of PLWH, and as they have begun to live longer, the number of patients with chronic HIV infection has greatly increased. What was once acute inpatient care of the dying has become outpatient chronic disease management with an emphasis on a long-term balancing act that involves the consideration of comorbidities, drug interactions, and adverse drug events in an aging HIV population.

Projections suggest that there may soon be a shortage of HIV providers. To avoid the imminent shortfall of HIV specialists, PCPs to manage HIV infection, comorbidities, and sequelae is critical to meeting the demand for HIV care. The quality of HIV care experienced PCPs provide is substantially similar to that of infectious disease specialists, but research shows that nearly 40% of PCPs and residents do not feel comfortable providing comprehensive services for PLWH in all disease stages.

Target Audience:

HCPs specializing in: Infectious diseases, HIV, and internal medicine; physician assistants, nurse practitioners, and pharmacists who practice in infectious disease; and any other healthcare professionals with an interest in or who clinically encounter patients with HIV.

Commercial Support Disclosure: This activity is supported by educational grants from Merck and Gilead.

Learners may participate in this activity free of charge.

Release Date: August 02, 2020 -- Expiration Date: August 02, 2022

Faculty: David Cennimo, MD


Introduction, Disclosures

Epidemiology of and risk factors for HIV

  • Introduction
  • Statistics and risk factors

Recent HIV guideline updates

  • Diagnosis and screening recommendations
  • Transmission
  • Developing treatment plans
  • When to initiate treatment

Treatment of HIV/AIDS

  • Standards of care: the changing paradigms of chronic HIV management
    • The aging HIV population
    • Common comorbidities and drug-drug interactions
  • Maximizing adherence and efficacy, minimizing adverse events
    • Once-daily options
    • Single-tablet regimens and fixed-dose combinations
  • Recent approvals and emerging evidence for safety and efficacy
  • Patient cases

Barriers to optimal care in patients with HIV

  • Adherence to therapy
  • Modifiable risk factors
  • Racial/ethnic disparities

Summary, conclusions, and best practice recap

Learning Objectives

By the end of the session the participant will be able to:

  • Discuss highlights and changes within the most current HIV treatment guidelines, including the roles of fixed-dose combinations, single-tablet regimens, and once-daily treatment options.
  • Evaluate a treatment plan and suggest modifications for improvement, taking the following into account: patient preference, adherence, pill burden, comorbidity level, and drug-drug interactions.
  • Develop a treatment plan that optimizes safety and efficacy using patient cases.
  • Describe the challenges and barriers to care associated with treating patients with HIV.


ACCME Activity #201861261


Faculty Disclosure and Resolution of COI

As a provider of continuing medical education, it is the policy of ScientiaCME to ensure balance, independence, objectivity, and scientific rigor in all of its educational activities. In accordance with this policy, faculty and educational planners must disclose any significant relationships with commercial interests whose products or devices may be mentioned in faculty presentations, and any relationships with the commercial supporter of the activity. The intent of this disclosure is to provide the intended audience with information on which they can make their own judgments. Additionally, in the event a conflict of interest (COI) does exist, it is the policy of ScientiaCME to ensure that the COI is resolved in order to ensure the integrity of the CME activity. For this CME activity, any COI has been resolved thru content review ScientiaCME.

Faculty Disclosure: David J. Cennimo, MD, FACP, FAAP, FIDSA, AAHIVM, Assistant Professor of Medicine and Pediatrics, Rutgers New Jersey Medical School, has no relevant conflicts of interest to disclose.

Disclosures of Educational Planners: Charles Turck, PharmD, BCPS, BCCCP, CEO of ScientiaCME, has no relevant conflicts of interest to disclose.

Commercial Support Disclosure: This activity is supported by an educational grant from Gilead and Merck.


  • Read the learning objectives above
  • Take the Pre-Test (optional). Completion of the pre-test will help us evaluate the knowledge gained by participating in this CME activity.
  • View the online activity. You may view this is in more than one session, and may pause or repeat any portion of the presentation if you need to.
  • Minimum participation threshold: Take the post-test. A score of 70% or higher is required to pass and proceed to the activity evaluation.
  • Complete the activity evaluation and CME registration. A CE certificate will be emailed to you immediately.

Cultural/Linguistic Competence & Health Disparities

System Requirements

Windows 7 or above
Internet Explorer 8
*Adobe Acrobat Reader
Mac OS 10.2.8
Safari or Chrome or Firefox
*Adobe Acrobat Reader
Internet Explorer is not supported on the Macintosh

*Required to view Printable PDF Version

Perform Pre-Test (optional)

Please take a few minutes to participate in the optional pre-test. It will help us measure the knowledge gained by participating in this activity.

Additional Courses That Are Related To This Activity

Human immunodeficiency virus (HIV): Updates in care for the primary care physician

Novel antimicrobials and infectious disease practice: Research updates from ID Week 2019

HIV Prevention: The Role of Pre-Exposure Prophylaxis (HIV-PrEP)

Coronavirus disease 2019 (COVID-19) preparedness, facts, and management