In this online, self-learning activity:
Each year, an estimated 170,000 cases of prostate cancer are diagnosed. Although early prostate cancer may be cured with surgery or radiation therapy, more than 50% of men will experience recurrence after definitive treatment. The use of androgen deprivation therapy (ADT) for intermediate-risk, high-risk, and recurrent prostate cancer has greatly increased in the last 15 years, extending 10-year survival by nearly 25% compared with observation alone. New treatment options for advanced prostate cancer have further improved survival and increased the number of patients living with non-metastatic and metastatic castration-resistant prostate cancer (nmCRPC and mCRPC). Despite the established improvements in survival associated with hormonal treatments, ADT has been associated with well-characterized negative effects on bone health. Indeed, bone metastases and subsequent skeletal-related events (SREs) are the primary driver of both morbidity and mortality among people with CRPC. In a study of 2234 men aged 65 years or older with a diagnosis of CRPC, 40% experienced SREs over a median follow-up of 10.6 months. Maintaining bone health in patients with CRPC requires routine monitoring and proactive management.
The following healthcare professionals: urologists, medical and radiation oncologists, primary care physicians, nuclear medicine specialists and radiologists, and endocrinologists; physician assistants, nurse practitioners, and pharmacists who treat prostate cancer; and any other healthcare professionals who commonly care for patients with prostate cancer.
Commercial Support Disclosure: This program is supported by educational grants from AMGEN.
This activity is free of charge.
Release Date: July 31, 2020 -- Expiration Date: July 31, 2022
Faculty: Yung Lyou, MD, PhD
Faculty introduction, disclosures
Introduction content: cursory refresher and review of prostate cancer
· Prostate cancer disease states
· Castration-resistant vs castration-sensitive
· Metastatic vs non-metastatic
· Early vs advanced disease
· Bone health and complications
· Androgen-deprivation therapy
· Pain, quality of life, and morbidity/mortality
· Recent data supporting early identification of metastases (oligometastatic disease)
· Challenges associated with bone complications
Bone screening and monitoring in prostate cancer
· Conventional imaging
· New and emerging imaging modalities
· Identification, assessment, and management of disease and intervention adverse effects on patients
· Clinical trial outcomes
· Time to SREs
· Time to metastasis
· Pain and patient-reported outcomes
· A review of bone-targeted pharmacotherapy
Summary, conclusions, and best practice recap
By the end of the session the participant will be able to:
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Faculty Disclosure: Dr. Yung Lyou, MD, PhD, City of Hope Comprehensive Cancer Center,
has no relevant financial disclosures.
Disclosures of Educational Planners: Charles Turck, PharmD, BCPS, BCCCP, President of ScientiaCME, has no relevant financial disclosures.
Commercial Support Disclosure: This program is supported by educational grants from AMGEN
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