Growth hormone deficiency (GHD) is characterized by inadequate secretion of growth hormone by the pituitary gland. The condition may arise from a variety of causes, including tumors, radiation, medications, traumatic brain injury, or genetic defects. In children, GHD is characterized by pronounced short stature, defined as 2 or more standard deviations from the mean based on age and sex. Because short stature may be caused by a variety of other factors, including genetics, hypothyroidism, and Turner syndrome, estimating the prevalence of GYHD in the pediatric population is challenging. Studies suggest that GHD may occur in 1 out of every 4,000 to 10,000 children. There is no gold standard for diagnosis of GHD in children. Clinical practice guidelines from the Pediatric Endocrine Society currently caution against the use of growth hormone provocation testing in the diagnosis of GHD given the unreliability of results. Auxology, biochemical evaluation, imaging, and physical examination remain the cornerstones of GHD diagnosis in children. Clinicians should be aware of appropriate strategies of diagnosis of GHD in pediatric patients, as improper diagnosis may delay effective treatment and increase risk for secondary complications.
The following healthcare professionals: Endocrinologists, pediatricians, and primary care physicians; physician assistants, nurse practitioners, and pharmacists who practice in endocrinology; and any other healthcare professionals with an interest in or who clinically encounter patients with GHD.
This program is supported by an educational grant from Sandoz.
Learners may participate in this activity free of charge.
Release Date: November 19, 2020 -- Expiration Date: November 19, 2022
Faculty: Dennis Styne, MD
Introduction, faculty disclosures
A brief primer: Epidemiologic, pathophysiologic, etiologic features, clinical signs and symptoms
Treatment options available for pediatric GHD
· - Investigational agents: Long-acting (e.g., somapacitan) and needle-less options
Summary, conclusions, and best practice recap
By the end of the session the participant will be able to:
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ABP MOC Recognition Statement: Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.0 MOC points in the American Board of Pediatrics's (ABP) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABP MOC credit.
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Faculty Disclosure: Dennis M. Styne, MD, Yocha Dehe Chair of Pediatric Endocrinology,
University of California, is a stockholder in Bristol Myers Squibb and Teva.
Disclosures of Educational Planners: Charles Turck, PharmD, BCPS, BCCCP, CEO of ScientiaCME, has no relevant conflicts of interest to disclose.
Disclosures of Peer Reviewers:
Michael Gottschalk, MD, PhD has no relevant financial disclosures.
Colin P. Hawkes, MD, PhD has no relevant financial disclosures.
Commercial Support Disclosure: This program is supported by an educational grant from Sandoz.
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