Faculty introduction, disclosures

Differential Diagnosis of GPP o    Common causes of AGEP  o    How to distinguish GPP from other diagnostic entities in clinical presentation  - DRESS, AGEP, disseminated candida, mycoplasma, sub-corneal pustular dermatosis, Ofuji's syndrome o    Labs and other features that can be useful to distinguish differential diagnoses of patients with pustules

GPP diagnostic and therapeutic considerations Clinical clues, including nail changes, to look for in GPP patients Therapeutic options for the treatment of GPP o    Appropriate therapies & their dosages - Focus on two randomized controlled trials including spesolimab o    Adverse effects o    Specialized patient considerations: pregnant patients, IL36RN mutation status, underlying organ dysfunction

Summary of clinical and therapeutic pearls, conclusions

By the end of the session the participant will be able to:

• Describe ways in which GPP may be distinguished from other dermatologic conditions in the differential diagnosis, and apply that information to a patient case.
• Use labs and other diagnostic tools to refine the differential of a patient with a widespread pustular eruption.
• Discuss the ways in which physical examination of the skin and nails improves diagnostic ability in a patient presenting with widespread pustules.
• Recall conventional and newer therapies for GPP and their mechanisms of action, dosing, and side effects, and apply that information to a patient case.

ACCME Activity #202547079

ACCREDITATION FOR THIS COURSE HAS EXPIRED. YOU MAY VIEW THE PROGRAM, BUT CME / CE IS NO LONGER AVAILABLE AND NO CERTIFICATE WILL BE ISSUED.

As a provider of continuing medical education, it is the policy of ScientiaCME to ensure balance, independence, objectivity, and scientific rigor in all of its educational activities. In accordance with this policy, faculty and educational planners must disclose any significant relationships with commercial interests whose products or devices may be mentioned in faculty presentations, and any relationships with the commercial supporter of the activity. The intent of this disclosure is to provide the intended audience with information on which they can make their own judgments. Additionally, in the event a conflict of interest (COI) does exist, it is the policy of ScientiaCME to ensure that the COI is resolved in order to ensure the integrity of the CME activity. For this CME activity, any COI has been resolved thru content review by ScientiaCME.

Disclosures of Faculty: Scott Worswick, MD, Associate Clinical Professor, Department of Dermatology, Keck School of Medicine of USC, has received financial compensation from Boehringer Ingelheim for consulting and speaker's bureau work.

Disclosures of Educational Planners: Charles Turck, PharmD, BCPS, BCCCP, President of ScientiaCME, has no relevant financial disclosures.

Faculty WILL discuss off-label uses of a commercial product.

All relevant financial relationships have been mitigated.

ScientiaCME adheres to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education. Any individuals in a position to control the content of a CE activity, including faculty, planners, reviewers or others are required to disclose all relevant financial relationships with ineligible entities (commercial interests). All relevant conflicts of interest have been mitigated prior to the commencement of the activity.

Commercial Support Disclosure: This program is supported by an educational grant from Boehringer Ingelheim Pharmaceuticals.

• Read the learning objectives above
• Take the Pre-Test (optional). Completion of the pre-test will help us evaluate the knowledge gained by participating in this CME activity.
• View the online activity. You may view this is in more than one session, and may pause or repeat any portion of the presentation if you need to.
• Minimum participation threshold: Take the post-test. A score of 70% or higher is required to pass and proceed to the activity evaluation.
• Complete the activity evaluation and CME registration. A CE certificate will be emailed to you immediately.

Cultural/Linguistic Competence & Health Disparities

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