Faculty introduction and disclosures

Introductory content  Epidemiology  Health burden  Clinical, metabolic, and pathophysiologic features  CGL & AGL  Congenital partial lipodystrophy: familial, CAV1 mutation  HIV-associated and other acquired partial lipodystrophies

Treatment considerations for lipodystrophic syndromes, including guideline-based approaches and clinical trial evidence  Goals of therapy  Broad overview of management  Dietary approaches  Management of metabolic complications  Dyslipidemia  Insulin resistance, diabetes  Condition-specific treatment  Persistent metabolic disturbance and leptin deficiency in generalized lipodystrophy: leptin analog  HIV-associated lipodystrophy  Optimizing antiretroviral therapy  GHRH analogue  Assessment of treatment response  Treatment challenges and gaps in care  Patient case(s)

Summary and conclusion

By the end of the session the participant will be able to:

• Summarize challenges related to the health burden, recognition, management, and prevention of lipodystrophic syndromes.
• Identify present treatments for different forms of lipodystrophy.
• Compose a plan of care for a patient with a lipodystrophy.

ACCME Activity #202612337

ACCREDITATION FOR THIS COURSE HAS EXPIRED. YOU MAY VIEW THE PROGRAM, BUT CME / CE IS NO LONGER AVAILABLE AND NO CERTIFICATE WILL BE ISSUED.

As a provider of continuing medical education, it is the policy of ScientiaCME to ensure balance, independence, objectivity, and scientific rigor in all of its educational activities. In accordance with this policy, faculty and educational planners must disclose any significant relationships with commercial interests whose products or devices may be mentioned in faculty presentations, and any relationships with the commercial supporter of the activity. The intent of this disclosure is to provide the intended audience with information on which they can make their own judgments. Additionally, in the event a conflict of interest (COI) does exist, it is the policy of ScientiaCME to ensure that the COI is resolved in order to ensure the integrity of the CME activity. For this CME activity, any COI has been resolved thru content review by ScientiaCME.

Disclosures of Faculty: Abhimanyu Garg, MD, Professor in the Department of Internal Medicine, Director of Metabolic Diseases, UT Southwestern Medical Center, has received financial compensation from consulting work and/or research grants from Amryt Pharmaceuticals, Regeneron Pharmaceuticals, Akcea Pharmaceuticals, Intercept Pharmaceuticals, Arrowhead Pharmaceuticals, Kyttaro Pharmaceuticals, and Third Rock Ventures.

Disclosures of Educational Planners: Charles Turck, PharmD, BCPS, BCCCP, President of ScientiaCME, has no relevant financial disclosures.

Faculty WILL NOT discuss off-label uses of a commercial product.

All relevant financial relationships have been mitigated.

ScientiaCME adheres to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education. Any individuals in a position to control the content of a CE activity, including faculty, planners, reviewers or others are required to disclose all relevant financial relationships with ineligible entities (commercial interests). All relevant conflicts of interest have been mitigated prior to the commencement of the activity.

Commercial Support Disclosure: This program is supported by an educational grant from Amryt Pharmaceuticals.

• Read the learning objectives above
• Take the Pre-Test (optional). Completion of the pre-test will help us evaluate the knowledge gained by participating in this CME activity.
• View the online activity. You may view this is in more than one session, and may pause or repeat any portion of the presentation if you need to.
• Minimum participation threshold: Take the post-test. A score of 70% or higher is required to pass and proceed to the activity evaluation.
• Complete the activity evaluation and CME registration. A CE certificate will be emailed to you immediately.

Cultural/Linguistic Competence & Health Disparities

*Required to view Printable PDF Version