In this online CME self-learning program:
Acute lymphoblastic leukemia (ALL) is one of a group of malignancies caused by cytogenetic DNA mutations of developing hematopoietic stem cell precursors and mostly common to children with peak incidence at 2-5 years of age. Although approximately 80% of ALL cases present in children, they also occur in adults. The symptoms of ALL are non-specific and similar to those of acute myelogenous leukemia (ALL), which patients usually have 1-3 months of complaints. These symptoms include: fatigue, malaise, or palpitations associated with anemia; fever with or without infection due to leukopenia or leukocytosis; and petechiae, and bleeding or bruising of the oral mucosa, skin, or gastrointestinal tract due to thrombocytopenia. Treatment goal in patients with ALL is to cure (which is defined as remission for at least 5 years), with children commonly responding to treatment with better than adults. Children may have a remission rate of 99% with a cure rate of about 90%, whereas adults have remission rates of only 60-85% with only 30-40% reaching 5-year disease-free survival. Treatments are categorized into five phases: remission induction with CNS prophylaxis, consolidation therapy, interim maintenance, delayed intensification, and maintenance therapy. Despite the high rate of cure in patients, possible complications and barriers to care in the treatment of ALL are adverse effects, expensive cost of treatment, or poor diagnosis. Dozens of agents that directly target biochemical pathways essential to neoplastic processes have been recently discovered and have been studied specifically in ALL, some of which are FDA-approved for ALL, others of which are presently in clinical trials. Helping the clinician discern the role of both cytotoxic and more novel therapies merits continuing education programming in ALL.
Agenda
Epidemiology of ALL |
ALL Morphology |
WHO 2008 ALL Classification |
Cytogenetic subtypes |
Ph-like Precursor B-Cell ALL |
ALL prognostic indicators |
T-Cell ALL |
ALL Management |
Risk of CNS Disease |
Immunotherapy of ALL |
Relapsed/refractory ALL |
Ph+ ALL |
Future Directions |
Healthcare professionals specializing in: hematology, oncology, pharmacy, and those who otherwise commonly care for patients with ALL.
Commercial Support Disclosure: This program is supported by educational grants from Sigma-Tau.
Release Date: June 30, 2015 -- Expiration Date: June 30, 2017
Faculty: Jonathan Kolitz, MD
By the end of the session the participant will be able to:
CME for this program is Expired.
As a provider of continuing medical education, it is the policy of ScientiaCME to ensure balance, independence, objectivity, and scientific rigor in all of its educational activities. In accordance with this policy, faculty and educational planners must disclose any significant relationships with commercial interests whose products or devices may be mentioned in faculty presentations, and any relationships with the commercial supporter of the activity. The intent of this disclosure is to provide the intended audience with information on which they can make their own judgments. Additionally, in the event a conflict of interest (COI) does exist, it is the policy of ScientiaCME to ensure that the COI is resolved in order to ensure the integrity of the CME activity. For this CME activity, any COI has been resolved thru content review ScientiaCME.
Faculty Disclosure: Jonathan Kolitz, MD has no relevent financial disclosures.
Disclosures of Educational Planners: Charles Turck, PharmD is an officer and part owner of ScientiaCME, LLC.
Commercial Support Disclosure: This program is supported by educational grants from Sigma-Tau.
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