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CME: Primary Immunodeficiency: Updates to Screening & Treatment


Activity Description / Statement of Need:

In this online CME self-learning program:


Primary immunodeficiency disease (PID or PIDD) is a group of conditions encompassing more than 300 different genetic immune deficiencies. The heterogeneous etiology of PID leads to a vast array of clinical presentations, including infection, malignancy, autoimmunity, and inflammation.Once thought to be exceedingly rare, PID is increasingly being recognized as an underdiagnosed disease affecting approximately 6 million people worldwide – and about 1 in 1,200 people in the US.





Introduction, Disclosures

Introduction content: cursory refresher and review of PID: Epidemiology & Classification [Objective 1]

  • PID overview and review
    • Increasing incidence and prevalence
    • Large numbers of undiagnosed patients
    • Adult versus child patient populations
    • Classifying PID
      • 2015 AAAAI practice parameter classifications
      • 2015 IUIS classifications
      • Diagnosing PID
        • Useful algorithms
        • Importance of site of infection and type of pathogen
        • Thorough family histories

Treatment Options for PID [Objective 2]

  • Hematopoietic stem cell transplantation
  • Immunoglobulin therapy
  • Antibiotic prophylaxis
  • Other therapies
    • Gamma interferon therapy
    • Gene therapy
    • PEG adenosine deaminase
    • Granulocyte-stimulating factor
    • Physiotherapy to improve breathing
    • Selection of treatments with 2015 practice parameter

Target Audience:

The following healthcare professionals: immunologists and primary care physicians; physician assistants, nurse practitioners, nurses, and pharmacists who practice in immunology; and any other healthcare professionals with an interest in or who clinically encounter patients with PID.

This program is supported by an educational grant from Grifols.

Release Date: June 16, 2017 -- Expiration Date: June 16, 2019

Faculty: Asal Gharib, MD


Learning Objectives

By the end of the session the participant will be able to:

  • List early signs and symptoms of primary immunodeficiency (PID), and employ appropriate diagnostic techniques to identify patients with PID
  • Describe appropriate treatment regimens for PID, including the use of Ig replacement therapy and antibiotic prophylaxis when appropriate, and apply them to patient cases
  • Describe the various options for Ig replacement therapy and implement routine monitoring procedures to ensure effectiveness
  • Individualize treatment plans with a focus on patient- and disease-related factors unique to PID



Faculty Disclosure and Resolution of COI

 As a provider of continuing medical education, it is the policy of ScientiaCME to ensure balance, independence, objectivity, and scientific rigor in all of its educational activities. In accordance with this policy, faculty and educational planners must disclose any significant relationships with commercial interests whose products or devices may be mentioned in faculty presentations, and any relationships with the commercial supporter of the activity. The intent of this disclosure is to provide the intended audience with information on which they can make their own judgments. Additionally, in the event a conflict of interest (COI) does exist, it is the policy of ScientiaCME to ensure that the COI is resolved in order to ensure the integrity of the CME activity. For this CME activity, any COI has been resolved thru content review ScientiaCME.


Faculty Disclosure:  Asal Gharib, M.D., University of California, Irvine Assistant Professor of Health Sciences Assistant Program Director Department of Immunology has no relevant conflicts of interest to disclose.


Disclosures of Educational Planners: Charles Turck, PharmD has no relevant conflicts of interest to disclose.


Commercial Support Disclosure: This program is supported by an educational grant from Grifols.


  • Read the learning objectives above
  • Take the Pre-Test (optional). Completion of the pre-test will help us evaluate the knowledge gained by participating in this CME activity.
  • View the online activity. You may view this is in more than one session, and may pause or repeat any portion of the presentation if you need to.
  • Minimum participation threshold: Take the post-test. A score of 70% or higher is required to pass and proceed to the activity evaluation.
  • Complete the activity evaluation and CME registration. A CE certificate will be emailed to you immediately.

Cultural/Linguistic Competence & Health Disparities

System Requirements

Windows 7 or above
Internet Explorer 8
*Adobe Acrobat Reader
Mac OS 10.2.8
Safari or Chrome or Firefox
*Adobe Acrobat Reader
Internet Explorer is not supported on the Macintosh

*Required to view Printable PDF Version

Perform Pre-Test (optional)

Please take a few minutes to participate in the optional pre-test. It will help us measure the knowledge gained by participating in this activity.

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