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CME: Parkinson's disease: Optimizing pharmacotherapeutic management strategies and addressing clinical challenges

Activity Description / Statement of Need:

In this online CME self-learning program:

Parkinson's disease (PD), a central nervous system disease of the autonomic and basal ganglia, neocortex, and spinal cord, is thought to affect about one million people in the United States. Its etiology is thought to include a confluence of factors including age, genetic predisposition, comorbid disease states (e.g., Gaucher’s disease), and environmental factor dynamics. Present in 1% of people over age 65 and 2.5% of those older than 80, its symptoms are the direct result of dopaminergic neuronal degradation along the nigrostriatal tract and include bradykinesia, resting tremor, muscle rigidity, and gait disturbance.

Podcast available at: Apple Podcasts or wherever you get your podcasts.

Target Audience:

The following healthcare professionals: neurologists and primary care physicians; physician assistants, nurse practitioners, nurses, and pharmacists who practice in neurology; and any other healthcare professionals with an interest in or who clinically encounter patients with PD.

This program is supported by an educational grant from Acorda and UCB.

This activity is free of charge.

Release Date: July 16, 2019 -- Expiration Date: July 16, 2021

Faculty: Jessica Lehosit, DO



Faculty introduction, disclosures

Introduction content: cursory refresher and review of PD

  • Epidemiology & risk factors
  • Diagnosis: clinical
  • Clinical features, diagnostic criteria
  • Pathophysiology and disease progression
  • Patient case(s)

Treatment of PD

  • Treatment goals and guidelines
  • Impact of treatment early in the disease process
  • Present and emerging pharmacotherapy
  • Levodopa
  • Dopamine agonists
  • MAO B inhibitors
  • Amantadine
  • COMT inhibitors
  • Antioxidants
  • Neurotrophic factors
  • Alpha synuclein-targeted therapies
  • Repurposed therapies
  • Treatment-refractory disease and complications
  • Management of motor fluctuations and dyskinesia
  • Disease complications and other effects impacting quality-of-life
  • Updates in formulations and routes of administration (e.g., inhalation)
  • Other clinical pearls, including: what to do when response to therapy diminishes; recognition and treatment of non-motor symptoms
  • A distinction between disease progression and adherence to therapy
  • Barriers to care: optimizing patients’ adherence to their therapy and minimizing adverse effects
  • Patient case(s)

Summary, conclusions, and best practice recap

Learning Objectives

By the end of the session the participant will be able to:

  • Describe the pathophysiology and disease progression of PD and their impact on patient quality-of-life
  • Describe the common clinical presentation(s) of PD
  • Apply recent biomedical literature to the management of PD the primary disease, levodopa-related fluctuations in motor function and dyskinesia, and other disease complications and effects impacting quality-of-life
  • Identify the advances in the biomedical literature concerning PD and emerging treatment options
  • List challenges and barriers to care associated with treating patients with PD


This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education through ScientiaCME. ScientiaCME is accredited by the ACCME to provide continuing medical education for physicians.

Credit Designation: ScientiaCME designates this educational activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™ toward the AMA Physician's Recognition Award. Physicians should only claim credit commensurate with the extent of their participation in the activity.


ABIM MOC Recognition Statement: Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 0.75 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

PhysiciansFor maintenance of certification (MOC) credit, you must enter your board certification ID # and birth date correctly.  It is the learner's responsibility to provide this information completely and accurately at the completion of the activity. Without providing it, the learner will NOT receive MOC credit for this activity. 


ScientiaCME is accredited by the Accreditation Council for Pharmacy Education (ACPE) as a provider of continuing pharmaceutical education. This program is approved for 0.75 hours (0.075 CEUs) of continuing education.  Proof of participation will be posted to your NABP CPE profile within 4 to 6 weeks to participants who have successfully completed the post-test.   Participants must participate in the entire presentation and complete the course evaluation to receive continuing pharmacy education credit.  ACPE # 0574-0000-19-026-H01-P.  ACPE Accreditation effective 07/20/19 expires 07/20/21. This is a Knowledge (K)-type activity.

PharmacistsYou must enter your NABP # and birth date correctly so that proof of participation can be posted to your NABP CPE profile. It is the learner's responsibility to provide this information completely and accurately at the completion of the activity. Without providing it, the learner will NOT receive CPE credit for this activity.

Nurse Practitioners (NPs): The American Academy of Nurse Practitioners accepts AMA PRA Category 1 Credit(s)™ from organizations accredited by the ACCME.  ScientiaCME will provide NPs who successfully complete each activity with a certificate of participation indicating that the activity was designated for AMA PRA Category 1 Credit(s)™.

Physician Assistants: The American Academy of Physician Assistants accepts AMA PRA Category 1 Credit(s)™ from organizations accredited by the ACCME.

Faculty Disclosure and Resolution of COI

As a provider of continuing medical education, it is the policy of ScientiaCME to ensure balance, independence, objectivity, and scientific rigor in all of its educational activities. In accordance with this policy, faculty and educational planners must disclose any significant relationships with commercial interests whose products or devices may be mentioned in faculty presentations, and any relationships with the commercial supporter of the activity. The intent of this disclosure is to provide the intended audience with information on which they can make their own judgments. Additionally, in the event a conflict of interest (COI) does exist, it is the policy of ScientiaCME to ensure that the COI is resolved in order to ensure the integrity of the CME activity. For this CME activity, any COI has been resolved thru content review ScientiaCME.


Faculty Disclosures:


Dr. Jessica Lehosit, DO, Assistant Professor of Neurology, McGuire VAMC/VCU medical center, has no relevant conflicts of interest to disclose.

Disclosures of Educational Planners: Charles Turck, PharmD has no relevant conflicts of interest to disclose.

Commercial Support Disclosure: This program is supported by an educational grant from Acorda and UCB


  • Read the learning objectives above
  • Take the Pre-Test (optional). Completion of the pre-test will help us evaluate the knowedge gained by participating in this CME activity.
  • View the online activity. You may view this is in more than one session, and may pause or repeat any portion of the presentation if you need to.
  • Take the post-test
  • Complete the activity evaluation and CME registration. A CE certificate will be emailed to you immediately.

Cultural and Linguistic Competence

System Requirements

Windows 7 or above
Internet Explorer 8
*Adobe Acrobat Reader
Mac OS 10.2.8
Safari or Chrome or Firefox
*Adobe Acrobat Reader
Internet Explorer is not supported on the Macintosh

*Required to view Printable PDF Version

Perform Pre-Test (optional)

Please take a few minutes to participate in the optional pre-test. It will help us measure the knowledge gained by participating in this activity.

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