Faculty introduction, disclosures

Introductory content and review of AATD  Epidemiology Genetic features of AAT and associated phenotypes Lung disease risk factors Clinical presentation: Lung disease, liver disease, other extrapulmonary disease Disease course and complications Healthcare burden

Treatment of AATD The asymptomatic individual: monitoring Goals of care Present and emerging pharmacotherapy Candidates for augmentation therapy Available agents Efficacy and safety Monitoring Practical guidance around augmentation therapy Management of pulmonary, hepatic, and other extrapulmonary complications Investigational therapies Patient cases

Summary, conclusions, and best practice recap

By the end of the session the participant will be able to:

• Summarize the healthcare burden unique to patients with AATD and challenges to optimal management.
• Recall the impact of present and emerging pharmacotherapies for AATD and its complications.
• Formulate a treatment plan for a patient with AATD.

ACCME Activity #202380833

ACCREDITATION FOR THIS COURSE HAS EXPIRED. YOU MAY VIEW THE PROGRAM, BUT CME / CE IS NO LONGER AVAILABLE AND NO CERTIFICATE WILL BE ISSUED.

As a provider of continuing medical education, it is the policy of ScientiaCME to ensure balance, independence, objectivity, and scientific rigor in all of its educational activities. In accordance with this policy, faculty and educational planners must disclose any significant relationships with commercial interests whose products or devices may be mentioned in faculty presentations, and any relationships with the commercial supporter of the activity. The intent of this disclosure is to provide the intended audience with information on which they can make their own judgments. Additionally, in the event a conflict of interest (COI) does exist, it is the policy of ScientiaCME to ensure that the COI is resolved in order to ensure the integrity of the CME activity. For this CME activity, any COI has been resolved through content review by ScientiaCME.

Disclosure of Faculty: Alan F. Barker, MD, Professor of Medicine, Oregon Health & Science University, has received financial compensation for research from Grifols.

Disclosures of Educational Planners: Charles Turck, PharmD, BCPS, BCCCP, President of ScientiaCME, has no relevant financial disclosures.

Faculty WILL NOT discuss off-label uses.

All relevant financial relationships have been mitigated.

ScientiaCME adheres to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education. Any individuals in a position to control the content of a CE activity, including faculty, planners, reviewers or others are required to disclose all relevant financial relationships with ineligible entities (commercial interests). All relevant conflicts of interest have been mitigated prior to the commencement of the activity.

Commercial Support Disclosure: This program is supported by an educational grant from Grifols.

• Read the learning objectives above
• Take the Pre-Test (optional). Completion of the pre-test will help us evaluate the knowledge gained by participating in this CME activity.
• View the online activity. You may view this is in more than one session, and may pause or repeat any portion of the presentation if you need to.
• Minimum participation threshold: Take the post-test. A score of 70% or higher is required to pass and proceed to the activity evaluation.
• Complete the activity evaluation and CME registration. A CE certificate will be emailed to you immediately.

Cultural/Linguistic Competence & Health Disparities

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