In this online CME self-learning program:
Acute Lymphoblastic Leukemia:
Acute lymphoblastic leukemia (ALL) is one of a group of malignancies caused by cytogenetic DNA mutations of developing hematopoietic stem cell precursors and mostly common to children with peak incidence at 2-5 years of age. Although approximately 80% of ALL cases present in children, they also occur in adults. The symptoms of ALL are non-specific and similar to those of acute myelogenous leukemia (AML), which patients usually have 1-3 months of complaints.These symptoms include: fatigue, malaise, or palpitations associated with anemia; fever with or without infection due to leukopenia or leukocytosis; and petechiae, and bleeding or bruising of the oral mucosa, skin, or gastrointestinal tract due to thrombocytopenia. Although the precise etiology of ALL remains unknown, some cases have been associated with: exposure to ionizing, toxic chemicals, herbicides; genetic conditions such as Down’s syndrome, Fanconi syndrome, neurofibromatosis; viruses like human T-lymphotropic viruses 1 and 2 and Epstein-Barr virus.
Treatment goal in patients with ALL is to cure, with children commonly responding to treatment with better than adults. Children may have a remission rate of 99% with a cure rate of about 90%, whereas adults have remission rates of only 60-85% with only 30-40% reaching 5-year disease-free survival. Several biochemical pathways essential to the neoplastic process in ALL have been further elucidated, and additional treatments have been made available with potentially many more on the horizon. Helping the clinician discern the role of each of the first-line and more novel therapies based on the most up-to-date research merits continuing education programming in ALL.
Moreover, professional guidelines have been updated recently, and communicating related information to healthcare professionals in a timely manner is a demonstrated need. The literature suggests that practicing healthcare professionals are oftentimes unable to keep up with the steady publishing of literature and evolution of clinical practice, and awareness of professional guidelines is no exception. Recently published guidelines therefore also inherently suggest a gap in medical practice and justify the need for educational programming.
Faculty introduction, disclosures
Introduction content: cursory refresher and review
Updates in treatment in patients with ALL
Summary, conclusions, and best practice recap
Hematologist-oncologists, medical oncologists, oncology nurse practitioners, physician assistants who specialize in oncology, and any other healthcare professionals who otherwise come into regular clinical contact with and provide care for patients with ALL.
This program is supported by an educational grant from AMGEN
Release Date: September 10, 2016 -- Expiration Date: September 10, 2018
Faculty: Dan Douer, MD
By the end of the session the participant will be able to:
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As a provider of continuing medical education, it is the policy of ScientiaCME to ensure balance, independence, objectivity, and scientific rigor in all of its educational activities. In accordance with this policy, faculty and educational planners must disclose any significant relationships with commercial interests whose products or devices may be mentioned in faculty presentations, and any relationships with the commercial supporter of the activity. The intent of this disclosure is to provide the intended audience with information on which they can make their own judgments. Additionally, in the event a conflict of interest (COI) does exist, it is the policy of ScientiaCME to ensure that the COI is resolved in order to ensure the integrity of the CME activity. For this CME activity, any COI has been resolved thru content review ScientiaCME.
Faculty Disclosure: Dan Douer, MD, Clinical Professor of Medicine, Weill Cornel Medical College, discloses that he has received financial compensation from participation at advisory boards and/or research grants from Amgen and Baxalta.
Disclosures of Educational Planners: Charles Turck, PharmD is an officer and part owner of ScientiaCME, LLC.
Commercial Support Disclosure: This program is supported by an educational grant from AMGEN
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